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SINEMET may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuriaThis reaction will not be altered by boiling the urine specimenFalsenegative tests may result with the use of glucose-oxidase methods of testing for glucosuria.

These medicines may be affected by SINEMETor may affect how well the tablets workYou may need different amounts of your medicineor you may need to take different medicines.

Sporadic cases of a symptom complex resembling neuroleptic malignant syndromeNMShave been reported in association with dose reductions or withdrawal of certain antiparkinsonian agents such as levodopacarbidopa levodopaor carbidopa levodopa extended releaseThereforepatients should be observed carefully when the dosage of levodopa is reduced abruptly or discontinuedespecially if the patient is receiving neuroleptics.

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most patients have been adequately treated with doses of sinemet cr that provide 400 to 1600 mg of levodopa per day, administered as divided doses at intervals ranging from 4 to 8 hours during the waking day.

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