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There is a close correlation between treatment with calcitriol and the development of hypercalcaemia.

Because of improved calcium absorption from the gastrointestinal tractsome patients on Rocaltrolcalcitriolmay be maintained on a lower calcium intakePatients who tend to develop hypercalcemia may require only low doses of calcium or no supplementation at all.

Concomitant treatment with a thiazide diuretic increases the risk of hypercalcaemiaCalcitriol dosage must be determined with care in patients undergoing treatment with digitalisas hypercalcaemia in such patients may precipitate cardiac arrhythmiassee section 4.4

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