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Kidney diseaseKidney disease or reduced kidney function may cause this medication to build up in the bodycausing side effectsIf you have kidney problemsdiscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is neededYour doctor may want to test your liver function regularly with blood tests while you are taking this medication.

Symptoms associated with the discontinuation or dose reduction of REMERON Tablets have been reportedPatients should be monitored for these and other symptoms when discontinuing treatment or during dosage reductionA gradual reduction in the dose over several weeksrather than abrupt cessationis recommended whenever possibleIf intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatmentdose titration should be managed on the basis of the patient’s clinical responsesee PRECAUTIONS and ADVERSE REACTIONS

Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indicationsboth psychiatric and nonpsychiatricshould be alerted about the need to monitor patients for the emergence of agitationirritabilityunusual changes in behaviorand the other symptoms described aboveas well as the emergence of suicidalityand to report such symptoms immediately to health care providersSuch monitoring should include daily observation by families and caregiversPrescriptions for REMERONmirtazapineTablets should be written for the smallest quantity of tablets consistent with good patient managementin order to reduce the risk of overdose.

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patients 24 years of age or younger may experience suicidal thoughts when they first take remeron or any other antidepressant.

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