Notably, the accuracy of imputation for variants with MAF>0.20 was also very high (median MAS=0.99; mean MAS=0.98), of key relevance given the allele frequency of the lead tag SNP from milk fat percentage association analysis (BovineHD0500026662 MAF=0.27 in the reference population, MAF=0.41 in the RNA seq cohort). Assuming that the BovineHD0500026662 GWAS tag SNP was in moderate LD with the underlying QTL, these data suggested that the vast majority of candidate causative variants would be accurately imputed in this sample. These comparisons used 790 SNPs common to both imputed genome and RNA seq derived genotype sets, where variants called from the RNA seq alignments were used to assess sequence imputation accuracy in these 406 animals.
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Fans of the Smart ForTwo who couldn’t quite live with just two seats should rejoice at the ForFour It’s a five door version, adding a bit of extra external footprint but a whole lot of extra versatility.It retains the hallmarks of previous Smarts such as the rear mounted engine, a visible external safety shell that’s painted a different colour from the body (known as Tridion) and an extremely tight turning circle, which makes it great for city driving. Best city cars to buy at the momentThe ForFour has the same pair of three cylinder petrol engines as the ForTwo a conventional 1.0 litre unit and a turbocharged 0.9. The size of the engines means that running costs are low but the Smart’s high price counts against it.It’s also not as composed or refined to drive as the cheaper VW up!, while the boot remains pretty small and the rear seats are more for occasional use.
The glass doors add an attractive look to the fireplace as you can see the flames through the insert. Fireplace Inserts can be either be fitted plush into the opening of the fireplace, or may extend out into the hearth. The major benefit of the extending fireplace insert is that it can add to the efficiency of the fireplace as heat extends out from the top, bottom and sides of the fireplace.
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Last season the rookie quarterback earned some fans simply by offering an alternative to the Michael Vick turnover nightmare. But Foles didn exactly put up dazzling numbers. In seven games last season, he threw a modest six touchdown passes along with five interceptions and eight fumbles on his way to a 1 5 record as a starter.
A. He is playing well. He has pace all around him and a centre forward in front, so there are plenty of options for him to show his range of passing and he is enjoying it. They eat the roots of different plants and grasses. This destroys the turf in the parks, lawns and golf courses. If there are about 5 to 6 grubs per square foot of your lawn or garden, then it is definitely the time to take some action and control their growth..
If you actually know me, you would know I’m a people pleaser and although I’m incredibly strong willed and confrontational, I struggled to be forthright with Tim in the first few months of our relationship. I didn’t want to come across difficult, so when he said he wanted half of the proceeds, I went along with it, something I have never, ever done before. I’m so angry with myself and I apologise.” .