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There are no adequate and well-controlled studies in pregnant womenIn nonclinical studies in miceratsand rabbitsgabapentin was developmentally toxic when administered to pregnant animals at doses similar to or lower than those used clinicallyNEURONTIN should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Advise patients that NEURONTIN may cause dizzinesssomnolenceand other symptoms and signs of CNS depressionOther drugs with sedative properties may increase these symptomsAccordinglyalthough patientsability to determine their level of impairment can be unreliableadvise them neither to drive a car nor to operate other complex machinery until they have gained sufficient experience on NEURONTIN to gauge whether or not it affects their mental and/or motor performance adverselyInform patients that it is not known how long this effect lastssee WARNINGS AND PRECAUTIONS

3NEURONTIN may cause serious or lifethreatening allergic reactions that may affect your skin or other parts of your body such as your liver or blood cellsThis may cause you to be hospitalized or to stop NEURONTINYou may or may not have a rash with an allergic reaction caused by NEURONTINCall a healthcare provider right away if you have any of the following symptoms:

Safety and effectiveness of NEURONTIN in the management of postherpetic neuralgia in pediatric patients have not been established.

When gabapentin is administered with morphinepatients should be observed for signs of central nervous systemCNSdepressionsuch as somnolencesedation and respiratory depressionsee CLINICAL PHARMACOLOGY

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according to the san francisco chronicle , off-label prescriptions accounted for roughly 90 percent of neurontin sales.

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