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Do not use Cozaar if you are pregnantIf you become pregnantstop taking this medicine and tell your doctor right awayLosartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

In patients with mild-to-moderate hepatic impairment the recommended starting dose of COZAAR is 25 mg once dailyCOZAAR has not been studied in patients with severe hepatic impairmentsee Use In Specific Populations and CLINICAL PHARMACOLOGY

Control of high blood pressure should be part of comprehensive cardiovascular risk managementincludingas appropriatelipid controldiabetes managementantithrombotic therapysmoking cessationexerciseand limited sodium intakeMany patients will require more than 1 drug to achieve blood pressure goalsFor specific advice on goals and managementsee published guidelinessuch as those of the National High Blood Pressure Education Program’s Joint National Committee on PreventionDetectionEvaluationand Treatment of High Blood PressureJNC

It is not recommended in children with glomerular filtration rate 2as no data are availablesee also section 4.4

As a consequence of inhibiting the renin-angiotensin-aldosterone systemchanges in renal function including renal failure have been reported in patients at riskthese changes in renal function may be reversible upon discontinuation of therapysee section 4.4

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