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1Relatively marked affinity for androgen receptorsless marked affinity for progesterone receptors and least affinity for oestrogen receptorsDanazol is a weak androgen but in addition antiandrogenicprogestogenicantiprogestogenicoestrogenic and antioestrogenic actions have been observed.

Datafrom two case-control epidemiological studieswere pooled to examine the relationship between endometriosisendometriosis treatments and ovarian cancerThese preliminary results suggest that the use of danazol might increase the baseline risk of ovarian cancer inpatients treated for endometriosis.

Danazol should be given as a continuous coursedosage being adjusted according to the severity of the condition and the patient’s responseA reduction in dosage once a satisfactory response has been achieved may prove possibleIn fertile femalesDanazol should be started during menstruationpreferably on the first dayto avoid exposing a pregnancy to its possible effectsWhere doubt existsappropriate checks should be made to exclude pregnancy before starting medicationFemales of child-bearing age should employ non-hormonal contraception throughout the course of treatment.

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an overdose of danazol is not expected to produce life threatening symptoms.

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