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Th inhibitoy activity aciclovi is highly slctiv du tits ainity th nzym thymidin kinas (TK) ncodd by HSV and VZV. This vial nzym convts aciclovi intaciclovi monophosphat, a nuclotid analogu. Th monophosphat is uth convtd intdiphosphat by cllula guanylat kinas and inttiphosphat by a numb cllula nzyms. In vit, aciclovi tiphosphat stops plication th hps vial DNA. This is accomplishd in th ways: 1) comptitiv inhibition vial DNA polymas; 2) incopoation intand tmination th gowing vial DNA chain; and 3) inactivation th vial DNA polymas. Th gat antivial activity aciclovi against HSV compad with VZV is du tits micint phosphoylation by th vial TK.

ACIVI Cam is intndd cutanous us only and should not b usd in th ys insid th mouth, nos vagina as it may caus iitation. ACIVI Cam should only b usd on hps labialis on th actd xtnal aspcts th lips and ac. Aciclovi cam has a potntial iitation and contact snsitization. Th ct aciclovi cam has not bn stablishd in immunocompomisd patints.

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